AinaDara — Vancomycin TDM Calculator

Population PK → recommends starting dose & loading dose. Switch to Steady State Trough once a steady-state level is available.

Patient Demographics

Age

Sex

Total Body Weight

Height

Renal Function

Serum Creatinine

mg/dL

Dosing Weight for CrCl

Cockcroft-Gault • AdjBW auto if TBW >20% above IBW

Baseline SCr (optional — for AKI detection)

mg/dL

Known AKI

Regimen Preferences

Preferred Interval

Infusion Duration

Standard: 1g/hr

Dose is auto-calculated from population PK. Interval suggestion based on CrCl shown above.

Loading Dose

Calculates a loading dose to hit target peak. Uses Vd×1.25 — distribution volume is larger at therapy start

Target peak concentration

mg/L

Time to first maintenance dose

From start of LD infusion · leave blank to match dosing interval

PK Model

Clearance Model

Volume of Distribution Model

Therapeutic Target

Trough Target Range

min

max

mg/L — default 10–20; severe infections 15–20

MIC (for AUC:MIC)

mg/L

Enter patient parameters and press Calculate

Bayesian Precision Dosing

Buelga 2005 · 1-Compartment · Phase 2A

Model

ICU / Critically Ill / Complex PK (favors 2-comp Goti model)

Saved Profiles

Profiles are stored in this browser only (localStorage). Use de-identified labels — do not enter patient names, MRNs, or other PHI.

Patient Demographics

Age

Sex

Total Body Weight

Height

Renal Function

Serum Creatinine

mg/dL

Cockcroft-Gault · AdjBW auto if TBW >20% above IBW · Used as fallback if no serial SCr entries below

Serial SCr — Time-Varying Renal Function (optional)

SCr (mg/dL)	Date & Time
No SCr entries — Bayesian uses baseline SCr above

When entries are present, Bayesian uses the SCr closest in time to the last dose. Enables AKI/recovery trend detection.

Dosing Course History

Doses Administered

Dose (mg)	Inf (h)	Date & Time
No doses — press + Add Dose

Observed Vancomycin Levels

Conc (mg/L)	Date & Time
No levels — press + Add Level

Levels can be drawn at any time point (not restricted to trough). More levels → narrower AUC uncertainty.

Therapeutic Target

AUC₂₄ Target

mg·h/L

MIC

mg/L

ASHP/IDSA 2020: AUC₂₄ 400–600 mg·h/L · AUC/MIC ≥ 400 at MIC 1 mg/L

Enter patient demographics and dosing history, then press Run Bayesian Analysis.
Add observed vancomycin levels to individualize the estimate.

Continue Course

Individualized PK · no re-fit

Resumes dosing from a previously fitted Bayesian run. Uses the stored individual PK (CL, V) directly — no re-optimization. To incorporate a new level, switch to AUC Precision and re-run.

Select Saved Profile

Only profiles saved after running a Bayesian fit are listed.

Therapeutic Target

AUC₂₄ Target

mg·h/L

MIC

mg/L

Select a saved profile with a Bayesian fit to continue dosing with its individualized PK.